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Web and the fact that CMU is phasing out RFS. The trace collected on the internal network at AT&T Bell Laboratories shows a very low overall volume but contains a very high percentage of X connections. Given that most machines connected to this Ethernet are X-terminals and that most people work on the machine to which their X-terminal is connected, this is not surprising. Comparing the three external AT&T traces one can see the effects of certain network changes. Most traf c observed in the period between 18 November and 8 December are accesses to AT&T Bell Laboratories' World Wide Web server that is connected to this Ethernet segment. While the January dataset still contains such HTTP accesses it is dominated by HTTP traf c that originates at AT&T Labs Research but accesses other machines in the Internet. The nal dataset also contains all traf c between Lucent Bell Laboratories and AT&T Labs Research's Web server and between AT&T and Lucent Web server (using a different port number). After we accounted for this, the percentage of HTTP traf c is 65.83% and the percentage of SMTP traf c is 28.55%. This explains the huge difference in the number of collected packets.

Chemical camou age of antigenic determinants: "stealth" erythrocytes Proc Natl Acad Sci USA 1997, 94, 7566 7571 14 Scott, M D; Murad, K L; Eaton, J W The other blood substitute: antigenically inert erythrocytes In Advances in Blood Substitutes: Industrial Opportunities and Medical Challenges, Winslow, R M; Vandegriff, K D; Intaglietta, M (eds) Birkhauser, Boston, 1997, pp 133 150 15 Scott, M D; Murad, K L Cellular camou age: fooling the immune system with polymers Curr Pharm Des 1998, 4, 423 438 16 Murad, K L; Mahany, K L; Kuypers, F A; Brugnara, C; Eaton, J W; Scott, M D Structural and functional consequences of antigenic modulation of red cells with methoxypoly(ethylene glycol) Blood 1999, 93, 2121 2127 17 Murad, K L; Gosselin, E J; Eaton, J W; Scott, M D.

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Most antigens belong to this latter category Antibodies that speci cally recognize microbial antigens can, in combination with plasma proteins known as complement, lyse bacterial cells or neutralize virus Also microbes complexed with antibody are more readily phagocytized T cells recognize antigen that is presented via an antigen-presenting cell (APC) such as macrophages or dendritic cells APCs process and present short peptide fragments complexed with major histocompatibility (MHC) molecules on the surface of the APC This processing and presentation is required for T cell activation There are two major divisions of T cells that are distinguished by expression of different cell surface markers (CD4 and CD8) CD-4 cells are also know as T-helper cells because they provide help for B cell activation CD-8 cells are also known as cytotoxic T cells because they lyse cells expressing speci c viral or tumor antigens.

TABLE 15.2 Breakdown of TCP Connection Packets According to Application Type for a Subset of the Traces CMU Start End Type http X rfs smtp ftp pop telnet nntp nger custom printer proto other Number of packets with SYN=FIN ags CMU Internal AT&T External AT&T External AT&T External AT&T

9 Dec. 94 29 June 95 8 Dec. 95 18 Nov. 95 15 Jan. 96 15 Mar. 96 12 a.m. 12 a.m. 12 a.m. 12 a.m. 9 p.m. 1:30 p.m. 10 Dec. 94 31 June 95 23 Dec. 95 8 Dec. 95 19 Jan. 96 31 Mar. 96 3 p.m. 12 a.m. 12 a.m. 12 a.m. 10 a.m. 2:30 p.m. in % in % in % in % in % in % 10.26 3.44 31.17 13.92 3.71 6.60 1.24 5.77 3.79 2.16 9.62 2.65 5.63 25.14 6.95 14.86 11.14 3.73 9.26 2.57 4.10 2.00 3.65 1.45 8.68 6.38 2.86 42.05 0.00 11.78 0.28 0.01 1.45 0.01 0.07 0.00 2.23 11.69 27.58 93.94 0.02 0.00 0.12 2.62 0.06 0.46 0.03 0.09 0.69 0.00 0.05 1.92 84.48 0.08 0.00 3.25 1.75 0.37 0.66 0.02 0.01 4.35 0.00 2.80 2.23 7.26 0.00 0.00 3.15 0.09 0.00 0.03 0.00 0.00 0.00 0.00 89.05 0.42

As indicated above the thymus plays a key role in T cell differentiation Pre-T cells migrate from the bone marrow to the thymus As relatively immature cells, T cells express both CD4 and CD8 molecules As maturation progresses these cells undergo both positive and negative selection During positive selection only cells that bind to MHC with a certain af nity survive As a result of this process T cells become MHC restricted; that is, they will only respond to antigen presented in association with MHC Cells that survive positive selection are potentially able to respond to self proteins However, before T cells leave the thymus negative selection occurs during which self-reactive cells are removed or functionally inactivated During the course of positive and negative selection CD4+ CD8+ cells down-regulate the expression of one of these molecules such that mature T cells express only CD4 or CD8.

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